If you are interested in distributing a Mac version of kombilo which could be used by everyone, without installing anything else,
I can build a self-contained Mac OSX .app version from the windows exe using winebottler. The .app will contain all the required libraries as well as wine (the only drawback is that the file will be quite large : 700 MO).
That would certainly be welcome from my point of view, and if you like, I will be glad to host the file on the kombilo web site.Some further comments.
I have briefly been looking into building a "Python wheel" for Mac OS X. This would facilitate the installation of the native version insofar as compiling the C++ extension would be done when creating the wheel, rather than by the user during installation. However, the issue of installing (suitable) Tcl/Tk packages would remain, as far as I understand.
One could go on and create a fully self-contained package similar to the Windows package (using a tool like PyInstaller). This would not require Wine nor winebottler and hence would be much smaller, I suppose, but it would take more time to set things up properly. So for the moment I have postponed this, and the winebottler package could be a good alternative. (If you would like to investigate the wheel/pyinstaller route, I would also be glad to discuss this further.)